The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book.
The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there is much consideration of the structure-function relationship. In addition, the book correlates with and extends from Volume 68 of the series “Structure and Physics of Viruses: An Integrated Textbook”.
This book is directed primarily at professionals that work in the broad field of Structural Biology and will be of particular interest to Structural Virologists. The editors, David Bhella and Robin Harris, have much experience in virology and protein structure, respectively. Dr Bhella is Director of the Scottish Macromolecular Imaging Centre. Professor Robin Harris is the long-standing Series Editor of the Subcellular Biochemistry series. He has edited and contributed to several books in the series.
Table of Contents
Virus proteins and nucleoproteins – an overview.- A structural view of negative sense rna virus nucleocapsid protein and its functions beyond.- Viral rna-dependent rna polymerases. a structural overview.- Filovirus filament proteins.- Structure and function of influenza virus ribonucleoprotein.- Structural homology between nucleoproteins of ssrna viruses.- Zika virus envelope protein and antibody complexes.- The retrovirus capsid core.- Nucleoprotein intermediates in hiv-1 dna integration: structure and function of hiv-1 intasomes.- Oligomerization of retrovirus integrases.- Structure and function of the human respiratory syncytial virus m2-1 protein.- Filamentous bacteriophage proteins and assembly.- Protein-rna interactions in the single-stranded rna bacteriophages.- The bacteriophage head-to-tail interface.- Beyond channel activity: protein-protein interactions involving viroporins.- Protein complexes and virus-like particle technology.- The role of flaviviral proteins in the induction of innate immunity.