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The past thirty years have witnessed a revolution in the science of addiction, yet we still rely on outdated methods of treatment. Expensive new programs for managing addiction are also flourishing, but since they are not based in science, they offer little benefit to people who cannot afford to lose money or faith in their recovery.
Clarifying the cutting-edge science of addiction for both practitioners and general readers, The Thirteenth Step pairs stories of real patients with explanations of key concepts relating to their illness. A police chief who disappears on the job illustrates the process through which a drug can trigger the brain circuits mediating relapse. One person's effort to find a burrito shack in a foreign city illuminates the reward prediction error signaled by the brain chemical dopamine. With these examples and more, this volume paints a vivid, readable portrait of drug seeking, escalation, and other aspects of addiction and suggests science-based treatments that promise to improve troubling relapse rates. Merging science and human experience, The Thirteenth Step offers compassionate, valuable answers to anyone who hopes for a better handle on a confounding disease.
Markus Heilig is a physician scientist and one of the most highly cited addiction researchers of his generation. For the past decade, he has led one of the largest research programs on addictive disorders in the world at the National Institute on Alcohol Abuse and Alcoholism at the National Institutes of Health. He is a fellow of the American College of Neuropsychopharmacology and is an editor of leading scientific journals in the field.
Table of Contents
Acknowledgments 1. Us and Them 2. A Grocery Store That Closed 3. An Entity in Its Own Right 4. A Chronic, Relapsing Disorder 5. Man or Machine? 6. Histories, Brains, and Behaviors 7. The Pursuit of Happiness 8. The Dark Side of Addiction 9. Rash Actions 10. Turning On a Bright Light 11. Getting the Cue 12. A Strained Mind 13. Fathers and Sons 14. Molecular Culprits 15. Trick or Treatment 16. Please Behave 17. Pills for Addiction Ills 18. Pray If You Wish, but Please Take Your Meds First 19. The Journey Ahead Notes Index
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