The Promise of Low Dose Naltrexone Therapy: Potential Benefits in Cancer, Autoimmune, Neurological and Infectious Disorders

The Promise of Low Dose Naltrexone Therapy: Potential Benefits in Cancer, Autoimmune, Neurological and Infectious Disorders

by Elaine A. Moore, Samantha Wilkinson

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Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 for opiate and drug abuse treatment. When used at much lower doses in an off-label protocol referred to as low dose naltrexone (LDN), the drug has been shown to halt disease progression in Crohn's disease and certain cancers, to reduce symptoms in multiple sclerosis and autism, and to improve numerous autoimmune and neurodegenerative conditions, including Parkinson's disease and amyotrophic lateral sclerosis (ALS). Grounded in clinical and scientific research, this book describes the history of naltrexone, its potential therapeutic uses, its effects on the immune system, its pharmacological properties, and how the drug is administered. It also lists fillers and compounding pharmacies, doctors who prescribe LDN, and patient resources, and includes interviews with LDN patients and researchers.

Product Details

ISBN-13: 9780786452583
Publisher: McFarland & Company, Incorporated Publishers
Publication date: 01/22/2009
Series: McFarland Health Topics
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 223
Sales rank: 1,069,670
File size: 2 MB
Age Range: 18 Years

About the Author

Elaine A. Moore has worked in hospital laboratories for more than 30 years, primarily in immunohematology and toxicology. She is a freelance medical writer and laboratory consultant. For more information, visit her website at She lives in Sedalia, Colorado. Samantha Wilkinson is a patient advocate for multiple sclerosis and LDN. Through her website she educates patients about current LDN research. She lives in Edmonds, Washington.

Table of Contents

Table of Contents

Acknowledgments vi
Foreword by Yash Pal Agrawal, M.D., Ph.D. 1
Preface 5
Introduction 7

1. The War on Drugs—A History of Naltrexone 11
2. LDN in Autoimmune Diseases 29
3. LDN in Multiple Sclerosis 45
4. LDN in Neurodegenerative Disorders 61
5. LDN in Cancer 78
6. LDN in Autism Spectrum Disorders 95
7. LDN in Wound Healing and Infections 102
8. The Immune System and LDN in HIV/AIDS 108
9. The LDN Experience: A Patient’s Guide to LDN 126
10. The Potential Benefits and Future of LDN 148

Chapter Notes 159
Glossary 167
Appendix: Clinical Trials of LDN and Related Compounds 179
Resources 189
Index 209

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