The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

by Dale Bredesen


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The instant New York Times and Wall Street Journal bestseller

A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline.

Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. 
In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline.  Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene.
The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.

Product Details

ISBN-13: 9780735216204
Publisher: Penguin Publishing Group
Publication date: 08/22/2017
Pages: 320
Sales rank: 13,629
Product dimensions: 6.10(w) x 9.10(h) x 1.30(d)

About the Author

Dale Bredesen, M.D., is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his M.D. from Duke University Medical Center in Durham, North Carolina. He served as chief resident in neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH postdoctoral fellow. He held faculty positions at UCSF, UCLA, and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding president and CEO. He is the chief medical officer of MPI Cognition.

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Table of Contents

Part 1 The Alzheimer's Solution

1 Disrupting Dementia 3

2 Patient Zero 21

3 How Does It Feel to Come Back from Dementia? 31

4 How to Give Yourself Alzheimer's: A Primer 41

Part 2 Deconstructing Alzheimer's

5 Wit's End: From Bedside to Bench and Back 55

6 The God Gene and The Three Types of Alzheimer's Disease 93

Part 3 Evaluation and Personalized Therapeutics

7 The "Cognoscopy"- Where Do You Stand? 115

8 ReCODE: Reversing Cognitive Decline 171

9 Success and the Social Network: Two People's Daily Routines 219

Part 4 Maximizing Success

10 Putting It All Together: You Can Do It 233

11 This Is Not Easy-Workarounds and Crutches 249

12 Resistance to Change: Machiavelli Meets Feynman 261

Appendices 275

Acknowledgments 291

Notes 295

Index 299

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The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline 4.7 out of 5 based on 0 ratings. 3 reviews.
KCRWNYC_fanatic More than 1 year ago
I been waiting for this book for about 2 years now, every since I stumbled upon Dr. Bredesen's ground-breaking work at the Buck Institute for Aging (via a Cleveland Clinic or webinar, I believe) and his Aging papers. Both my parents, 79 and 81, suffer from varying degrees of dementia, and my father recently passed after hellish years of continued (but curiously not strictly linear) cognitive decline. While his death certificate says "Alzheimer's," he most certainly had a kind of metabolic dementia, probably a mix of the three types presented in this book: mostly Toxic, surely Cold/Atrophic and very likely Hot/Inflammatory. If only we had known of some of these tests 2-3 (or 10!) years ago. But also the trick and (huge) challenge is finding a physician and nursing team that is aware of this research and these revolutionary ideas. I can tell you that Bredesen's ideas have already begun to send shock waves throughout the medical community-- or at least that alert subset who make the effort both to continue their clinical education and to venture outside of classical medical school training. There will surely be those who dismiss his ideas, but they makes so much sense to me (as well as to alot of folks much smarter than I) and offer both affordable and immediately applicable therapeutic interventions unlike any other research or reasoning in this field in my lifetime. Bredesen is the first I know of to (A) challenge the prevailing (I would say clearly fallacious/misguided) understanding of Alzheimer's (and dementias generally) and also (B) sub-categorize different presentations in a way that opens up never before considered avenues for treatment. In this regard, he approaches this disease much the way we in Traditional Chinese Medicine (and other systems medicine folks, as those working in Functional (also called Restorative or Nutritional) Medicine) do: piecing together characteristics of a clinical presentation that suggest an archetype or pattern and, rather than asking, "What disease does this person have?" asking instead, "What kind of person (or, more specifically here, physiology) has this disease?" Because it's so packed with mind blowing information, the book can be a bit of slog at times-- even compared to similar titles that have come out this year like unDoctored (William Davis), The Plant Paradox (Steven Gundry) and Head Strong (Dave Asprey)-- but mostly this only reflects the extent of Dr. Bredesen's research and intellect. I am hoping, though, that the publisher or author will come out with a more approachable "highlights" summary as has been done with similar titles. (And maybe add summary tables for Type 1 (Inflammatory) and 2 (Atrophic) presentations the way they've done for Type 3 (Toxic).) Without a question this book is worth the effort for anyone touched by someone experiencing or at risk for (pretty much everyone) cognitive decline. From what I can tell, Bredesen's approach applies broadly to any and all dementias be they officially diagnosed as Alzheimer's or not. Please correct me, someone, if I am wrong. I hope to update this review as I continue to analyze and re-read this work-- and encourage conversations among clinicians and the public. I imagine Dr. Bredesen or his publisher will provide or has provided a venue for such.
Anonymous More than 1 year ago
I believe and his Aging papers. and Take a Barnes $10 Off coupons code from
Anonymous More than 1 year ago
If you want to know about dementia, and what can be done about it, get this book & digest it