Telomeres in Health and Disease

Telomeres in Health and Disease

by Elsevier Science

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Overview

This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field.

  • Contributions from specialists in telomere diseases
  • Informs and updates on how telomere dysfunction may cause disease in humans

Product Details

ISBN-13: 9780123979094
Publisher: Elsevier Science
Publication date: 06/26/2014
Series: ISSN , #125
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 202
File size: 8 MB

About the Author

Rodrigo Calado received his MD in 1997 and PhD in 2003 both from the University of São Paulo, Brazil. He was trained in hematology and did his postdoctoral fellowship at the U. S. National Institutes of Health in Bethesda, Maryland with Dr. Neal S. Young, where he also worked as a Staff Scientist between 2007 and 2011. He is currently Associate Professor of Medicine at the University of São Paulo in Ribeirão Preto, Brazil. Dr. Calado was the first to report on telomerase enzyme mutations in humans causing disease (aplastic anemia) and found that telomerase complex mutations also predisposed to leukemia and liver cirrhosis. He also demonstrated that short telomeres increase chromosome instability in humans and that sex hormones up-regulate telomerase function in hematopoietic cells.

Table of Contents

  1. Telomere and Telomerase Biology
    Miriam Aparecida Giardini, Marcela Segatto, Marcelo Santos da Silva, Vinícius Santana Nunes and Maria Isabel Nogueira Cano
  2. Human Telomeres and Telomere Biology Disorders
    Sharon A. Savage
  3. Telomere Biology in Stem Cells and Reprogramming
    Luis F. Z. Batista
  4. Telomere Dynamics and Aging
    Geraldine Aubert
  5. Telomeres in Molecular Epidemiology Studies
    Clara Bodelon, Sharon A. Savage and Shahinaz M. Gadalla
  6. Telomere dysfunction and hematologic disorders
    Raquel M. A. Paiva and Rodrigo T. Calado
  7. The Role of Telomeres in Liver Disease
    Yoshiaki Sunami, Guido von Figura, Alexander Kleger, Pavel Strnad, Norbert Hüser and Daniel Hartmann
  8. Telomeres in lung diseases
    Rodrigo T. Calado

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