Lucy, Karen, Mona, and Cheryl are selected by Joe, the CEO of the hospital, to boost morale and govern major changes within a rural hospital. They are to guide others in the areas of smoking cessation, exercise, weight loss, self-esteem, and absence of drug and alcohol usage. The group is formed based upon their reputation of positive character and experience. The Sisters are apprehensive about their new assignment, but hopeful.
Together these Silver Sisters bond to make improvements. There is no recipe for success. It is impossible to change another employee's behaviors. But the Sisters encourage each other as they launch into a new challenge. They support each other as they interact with many ill and dying people in the hospital and the community. They can also make the Silver Sister group work in the future through their faith.