The Power Puppies have brought the world back to safety, and Dr. Mittens and Dark Matter Cat are under control in Indiana. All is well… or is it? When a mole named Doug pops up in the cats’ daycare center of torture, they escape and frame the Power Puppies for a terrible crime. Imprisoned in Rome, the Power Puppies seem to have lost all hope until an online support group of super-powered rodents decides to help. In a fur-raising adventure with time travel, plots for world domination, mind control, and the Mona Lisa, the Power Puppies have to face the cats again. Will the members of the Rodent Room give them the boost they need, or will the dogs waste away in prison while Dr. Mittens and Dark Matter Cat roam free?