You can't always judge a book -- or a box set -- by its cover, but in the case of this retrospective of the artiest element in New York's first punk generation, it's fairly safe to do so. After all, the odd-sized (16 3/4" x 5 1/4"), uniquely constructed collection -- which looks more like a high-end art book than a set of compact discs -- fits perfectly with the off-kilter aesthetic that David Byrne and company exuded in their time together. Once in a Lifetime cherry-picks the Talking Heads' best-known material, from early churners like "Psycho Killer" to more ornate latter-day favorites like "Nothing but Flowers," but the set also puts more shadowy material into focus. The band's earliest singles, "Love Goes to Building on Fire" and "Uh, Oh Love Comes to Town," are not only aired but, in the case of the latter, presented in an alternate version laced with steel drums. Byrne even went back to the band's embryonic phase to cull the charmingly raw, previously unreleased "Sugar on My Tongue." Diehards will find other compelling cuts tucked away on the three audio discs: An alternate take of "Drugs" spotlights Robert Fripp's angular guitar line, while "A Clean Break," which never made it onto a studio album, is presented in a fast-and-furious concert setting. The collection is rounded out by a DVD version of the Heads' 1988 video collection, Storytelling Giant, expanded from its original issue by three clips, including the hazy "Sax and Violins" (the accompaniment for a song that appeared in Wim Wenders's Until the End of the World). The set's extensive 80-page booklet features commentaries from the band members and others, a detailed time line, and archival photos. There's plenty to free your mind in these grooves, and plenty of incentive for your ass to follow.