Pub. Date:
Springer Berlin Heidelberg
Molecular Biology of the SARS-Coronavirus / Edition 1

Molecular Biology of the SARS-Coronavirus / Edition 1

by Sunil K. LalSunil K. Lal


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SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.

Product Details

ISBN-13: 9783642036828
Publisher: Springer Berlin Heidelberg
Publication date: 02/19/2010
Edition description: 2010
Pages: 328
Sales rank: 922,125
Product dimensions: 6.20(w) x 9.20(h) x 1.00(d)

Table of Contents

Part I Viral Entry

1 Cellular Entry of the SARS Coronavirus: Implications for Transmission, Pathogenicity and Antiviral Strategies Ilona Glowacka Stephanie Bertram Stefan Pöhlmann 3

2 The Cell Biology of the SARS Coronavirus Receptor, Angiotensin-Converting Enzyme 2 Daniel W. Lambert 23

3 Structural Molecular Insights into SARS Coronavirus Cellular Attachment, Entry and Morphogenesis Daniel R. Beniac Timothy F. Booth 31

Part II Structures Involved in Viral Replication and Gene Expression

4 RNA Higher-Order Structures Within the Coronavirus 5' and 3' Untranslated Regions and Their Roles in Viral Replication Pinghua Liu Julian Leibowitz 47

5 Programmed -1 Ribosomal Frameshifting in SARS Coronavirus Jonathan D. Dinman 63

Part III Viral Proteins

6 Expression and Functions of SARS Coronavirus Replicative Proteins Rachel Ulferts Isabelle Imbert Bruno Canard John Ziebuhr 75

7 SARS Coronavirus Replicative Enzymes: Structures and Mechanisms Isabelle Imbert Rachel Ulferts John Ziebuhr Bruno Canard 99

8 Quaternary Structure of the SARS Coronavirus Main Protease Gu-Gang Chang 115

9 The Nucleocapsid Protein of the SARS Coronavirus: Structure, Function and Therapeutic Potential Milan Surjit Sunil K. Lal 129

10 SARS Coronavirus Accessory Gene Expression and Function Scott R. Schaecher Andrew Pekosz 153

11 SARS Accessory Proteins ORF3a and 9b and Their Functional Analysis Wei Lu Ke Xu Bing Sun 167

12 Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab Choong-Tat Keng Yee-Joo Tan 177

Part IV Viral Pathogenesis and Host Immune Response

13 SARS Coronavirus Pathogenesis and Therapeutic Treatment Design Timothy P. Sheahan Ralph S. Baric 195

14 Modulation of Host Cell Death by SARS Coronavirus Proteins Claudia Diemer Martha Schneider Hermann M. Schätzl Sabine Gilch 231

15 SARS Coronavirus and Lung Fibrosis Wei Zuo Xingang Zhao Ye-Guang Chen 247

16 Host Immune Responses to SARS Coronavirus in Humans Chris Ka-fai Li Xiaoning Xu 259

17 The Use of Retroviral Pseudotypes for the Measurement of Antibody Responses to SARS Coronavirus Nigel James Temperton 279

18 SARS Coronavirus Spike Protein Expression in HL-CZ Human Promonocytic Cells: Monoclonal Antibody and Cellular Transcriptomic Analyses T. Narasaraju P.L. Soong J. ter Meulen J. Goudsmit Vincent T.K. Chow 289

19 Signaling Pathways of SARS-CoV In Vitro and In Vivo Tetsuya Mizutani 305

Index 323

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