Epilepsy as a Dynamic Disease

Epilepsy as a Dynamic Disease

Paperback(Softcover reprint of hardcover 1st ed. 2003)

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A "brain defibrillator" may be closer than we think. An epileptic seizure involves a paroxysmal change in the activity of millions of neurons. Feedback control of seizures would require an implantable device that could predict seizure occurrence and then deliver a stimulus to abort it. To examine the feasibility of building such a device, this text brings together experts in epilepsy, bio-engineering, and dynamical systems theory. Topics include the development of epileptic systems, seizure prediction, neural synchronization, wave phenomena in excitable media, and the control of complex neural dynamics using brief electrical stimuli.

Product Details

ISBN-13: 9783642076657
Publisher: Springer Berlin Heidelberg
Publication date: 12/10/2010
Series: Biological and Medical Physics, Biomedical Engineering
Edition description: Softcover reprint of hardcover 1st ed. 2003
Pages: 417
Product dimensions: 6.10(w) x 9.25(h) x (d)

About the Author

As a young student, John Milton (1608-1674) dreamed of bringing the poetic elocution of Homer and Virgil to the English language. Milton realized this dream with his graceful, sonorous Paradise Lost, now considered the most influential epic poem in English literature. In sublime poetry of extraordinary beauty, Paradise Lost has inspired generations of artists and their works, ranging from the Romantic poets to the books of J. R. R. Tolkien.

Table of Contents

1 Medically Intractable Epilepsy.- 2 Insights into Seizure Propagation from Axonal Conduction Times.- 3 Dynamic Epileptic Systems Versus Static Epileptic Foci?.- 4 Neuroglia, the Other Brain Cells.- 5 The Electroencephalogram (EEG): A Measure of Neural Synchrony.- 6 Electrocorticographic Coherence Patterns of Epileptic Seizures.- 7 Synchronization of Synaptically-Coupled Neural Oscillators.- 8 Controling Neural Synchrony with Periodic and Aperiodic Stimuli.- 9 Modeling Pattern Formation in Excitable Media: The Legacy of Norbert Wiener.- 10 Are Cardiac Waves Relevant to Epileptic Wave Propagation?.- 11 Pattern Formation in the Microbial World: Dictyostelium Discoideum.- 12 Predicting Epileptic Seizures.- 13 Comparison of Methods for Seizure Detection.- 14 Direct Deep Brain Stimulation: First Steps Towards the Feedback Control of Seizures.- 15 Seizure Control Using Feedback and Electric Fields.- 16 Aborting Seizures with a Single Stimulus: The Case for Multistability.- 17 Unstable Periodic Orbits (UPOs) and Chaos Control in Neural Systems.- 18 Prospects for Building a Therapeutic Cortical Stimulator.- 19 Brain Defibrillators: Synopsis, Problems and Future Directions.- Color Plates.- References.

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