| George Clooney | Capt. Billy Tyne |
| Helen Hunt | Jo Harding |
| Josh Lucas | Dylan Johns |
| Bill Paxton | Bill Harding |
| Kurt Russell | Robert Ramsey |
| Mark Wahlberg | Bobby Shatford |
| Cary Elwes | Dr. Jonas Miller |
| Jacinda Barrett | Maggie James |
| John C. Reilly | Dale "Murph" Murphy |
| Diane Lane | Christine Cotter |
| Jami Gertz | Melissa |
| Richard Dreyfuss | Richard Nelson |
| Emmy Rossum | Jennifer Ramsey |
| Lois Smith | Aunt Meg |
| William Fichtner | David "Sully' Sullivan |
| John Hawkes | Michael "Bugsy" Moran |
| Allen Payne | Alfred Pierre |
| Mary Elizabeth Mastrantonio | Linda Greenlaw |
| Karen Allen | Melissa Brown |
Technical Credits
| Jan de Bont | Director |
| Wolfgang Petersen | Director |