| Dylan O'Brien | Thomas |
| Kaya Scodelario | Teresa |
| Thomas Brodie-Sangster | Newt |
| Giancarlo Esposito | Jorge |
| Aidan Gillen | Janson |
| Ki Hong Lee | Minho |
| Barry Pepper | Vince |
| Patricia Clarkson | Ava Paige |
| Rosa Salazar | Brenda |
| Dexter Darden | Frypan |
| Walton Goggins | Lawrence |
| Katherine McNamara | Sonya |
| Nathalie Emmanuel | Harriet |
| Will Poulter | Gally |
| Jacob Lofland | Aris |
| Paul Lazenby | Guard |
| Jake Curran | WCKD Lieutenant |
| Greg Kriek | Co Conductor |
| Devin Koehler | Guard |
| Dylan Smith | Jasper |
| Kazi Maubert | Immune Child |
| Scott Cooper | Station Chief |
| Parm Soor | Board Member |
Technical Credits
| Wes Ball | Director,Producer |
| Andrea Borland | Art Director |
| Marty Bowen | Producer |
| Darren Brisker | Sound Mixer |
| Denise Chamian | Casting |
| Jonathan Chiles | Sound Mixer |
| Nicole Connelly | Special Effects |
| Ryan Cronin | Animator |
| Dan Zimmerman | Editor |
| Johann deBeer | Makeup Special Effects |
| Michael Diner | Art Director |
| Daniel Dorrance | Production Designer |
| Danie duToit | Camera Operator |
| Ben Eadie | Special Effects Supervisor |
| Jazmin Evans | Animator |
| Alec Gillis | Makeup |
| Lee Gilmore | Sound/Sound Designer |
| Wyck Godfrey | Producer |
| Ellen Goldsmith-Vein | Producer |
| Paul Harb | Editor |
| Joe Hartwick | Producer |
| Sanja Milkovic Hays | Costumes/Costume Designer |
| Hugo Santiago | Art Director |
| Ross Jenkin | Art Director |
| Julieta Jimenez | Set Decoration/Design |
| John Paesano | Score Composer |
| Vincent Lascoumes | Asst. Director |
| Ai-Ling Lee | Sound/Sound Designer |
| Marike Liebetrau | Makeup Special Effects |
| Andrew Lee McConnell | Set Decoration/Design |
| Cordell McQueen | Special Effects Supervisor |
| T.S. Nowlin | Screenwriter |
| Patrick B. O'Brien | Co-producer |
| Gyula Pados | Cinematographer |
| Patrick Phan | Stunts |
| Tobias Poppe | Sound/Sound Designer |
| Siobhan Roome | Set Decoration/Design |
| Christa Schoeman | Makeup Special Effects |
| Georgina Selby | Production Manager |
| Daniel M. Stillman | Executive Producer |
| Lee Stollman | Producer |
| Gerald Sutherland | Makeup Special Effects |
| Areeg Sweis | Production Manager |
| Grant Van Der Slagt | Art Director |
