| David Andrews | Frank Borman |
| Bryan Cranston | Buzz Aldrin |
| Tim Daly | Jim Lovell |
| Al Franken | Jerome Weisner |
| Tony Goldwyn | Neil Armstrong |
| Chris Isaak | Ed White |
| Cary Elwes | Michael Collins |
| Brett Cullen | Dave Scott |
| Robert John Burke | Bill Anders |
| Peter Scolari | Pete Conrad |
| Nick Searcy | Deke Slayton |
| Lane Smith | Emmett Seaborn |
| Dan Lauria | James Webb |
| Mark Rolston | Gus Grissom |
| Mason Adams | Clinton Anderson |
| Ronny Cox | Lee Atwood |
| Dakin Matthews | Dr. Floyd Thompson |
| Kevin Pollak | Joseph Shea |
| Ben Marley | Roger Chaffee |
| Ruth Reid | Grissom,Betty |
| Joe Spano | George Mueller |
| Daniel Hugh Kelly | Gene Cernan |
| Stephen Root | Chris Kraft |
| Dann Florek | Robert Seamans |
| John Slattery | Sen. Walter Mondale |
| Ted Levine | Alan Shepard |
| Jim Hofvendahl | Thomas Stafford |
| Rhoda Griffis | Martha Chaffee |
| Ann Cusack | Jan Armstrong |
| Jo Anderson | Pat White |
| James Rebhorn | Harrison Storms |
| Sally Field | Actor |
Technical Credits
| Erik Bork | Co-producer |
| Michael Bostick | Producer |
| Chrisi Karvonides Dushenko | Costumes/Costume Designer |
| Ernest D. Farino | Special Effects Supervisor |
| Joe Foglia | Sound/Sound Designer |
| Brian Grazer | Producer |
| Tom Hanks | Executive Producer |
| Ron Howard | Producer |
| Liberman/Hirschfeld Casting | Casting |
| Beth Reed | Art Director |
| Bruce Richmond | Co-producer |
| Janace Tashjian | Co-producer |
| Gale Tattersall | Cinematographer |
| Tony To | Executive Producer |
| Richard Toyon | Production Designer |
