| Karl Urban | John Grimm |
| Rock | Beck,The Scorpion King/Mathayus,Sarge |
| Rosamund Pike | Samantha Grimm |
| Seann William Scott | Travis |
| Steven Brand | Memnon |
| Michael Clarke Duncan | Balthazar |
| Razaaq Adoti | Duke |
| Rosario Dawson | Mariana |
| Christopher Walken | Hatcher |
| Kelly Hu | Cassandra |
| Bernard Hill | Philos |
| Deobia Oparei | Destroyer |
| Ewen Bremner | Declan |
Technical Credits
| Andrzej Bartkowiak | Director |
| Chuck Russell | Director |
| Peter Berg | Director |