ISBN-10:
089042456X
ISBN-13:
9780890424568
Pub. Date:
02/22/2010
Publisher:
American Psychiatric Publishing, Incorporated
Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V

Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V

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Overview

Generalized anxiety disorder (GAD) and major depression (MD) form the largest group of common mental disorders. These two conditions often occur together, and emerging evidence suggests several similarities between them. As we move toward revising the Diagnostic and Statistical Manual of Mental Disorders for DSM-V, Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V explores the nosologic relationship between GAD and MD. In this comprehensive manual, more than 45 contributors cover a wide range of empirical and conceptual issues that face clinicians and researchers working with GAD and MD today.

This book acts as a guidepost for the entire DSM process. It reviews recent scientific advances in our understanding of the interrelationship between GAD and MD, summarizes the body of evidence into a few broad conclusions, and reflects on the implications of these findings for future nosologic efforts. The contributing authors review empirical data from a variety of perspectives — including genetics, biology, treatment, development, course, predictors, disability, and psychosocial stressors — and then integrate results from research on all these diverse validators to come up with a single "bottom-line" recommendation regarding the relationship between GAD and MD. In addition, the book considers conceptual issues, such as criteria for results from validators, the relevance of results on symptoms of anxiety and depression, weights of different classes of validators, and the rules for assigning disorders into categories. And finally, it addresses the question of what new kinds of data could be gathered that would help to clarify the relationship between MD and GAD more definitively. Each chapter includes tables, charts, and references to enhance the evidence presented on such diverse topics as: • A thorough review of the genetics of GAD and MD• The role of psychotropics in distinguishing between GAD and MD• Biological and treatment aspects of GAD and MD• Psychometric aspects of GAD and MD• Childhood risk factors associated with GAD and MD• Common mental disorders across cultures

Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V develops operationalized criteria for nosologic decisions that enable clinicians to bridge the gap between data to diagnostic recommendations. Not only does the methodology of investigating an active interchange between empirical and conceptual perspectives shed new light on the relationship between GAD and MD, but it also carries implications for the rest of DSM-V.

Product Details

ISBN-13: 9780890424568
Publisher: American Psychiatric Publishing, Incorporated
Publication date: 02/22/2010
Pages: 400
Product dimensions: 5.90(w) x 8.90(h) x 1.00(d)
Age Range: 18 Years

About the Author

David Goldberg, D.M., F.R.C.P., is Professor Emeritus at the Institute of Psychiatry, Health Service and Population Research, at King's College in London, England.

Kenneth S. Kendler, M.D., is Distinguished Professor in the Departments of Psychiatry and Human Genetics at the Virginia Institute for Psychiatric and Behavioral Genetics in the School of Medicine at Virginia Commonwealth University in Richmond, Virginia.

Paul J. Sirovatka, M.S. (1947—2007), was Director of Research Policy Analysis in the Division of Research and American Psychiatric Institute for Research and Education at the American Psychiatric Association in Arlington, Virginia.

Darrel A. Regier, M.D., M.P.H., is Executive Director of the American Psychiatric Institute for Research and Education and Director of the Division of Research at the American Psychiatric Association in Arlington, Virginia.

Table of Contents

Contributors ix

Preface Darrel A. Regier xvii

1 The Problem: Charge to the Conference Kenneth S. Kendler 1

2 The Nosologic Relationship between Generalized Anxiety Disorder and Major Depression John M. Hettema 15

Commentary on “The Nosologic Relationship Between Generalized Anxiety Disorder and Major Depression” Jules Angst Alex Gamma Vladeta Ajdacic Wulf Rössler 41

3 The Biology of Generalized Anxiety Disorder and Major Depressive Disorder: Commonalities and Distinguishing Features Elizabeth I. Martin Charles B. Nemeroff 45

4 What (No) Differences in Responses to Three Classes of Psychotropics Can Teach us About Distinctions Between Generalized Anxiety Disorder and Major Depressive Disorder Toshi A. Furukawa Norio Watanabe Ichiro M. Omori 71

Commentary On “The Biology of Gad and MDD” and “What (No) Differences in Responses to Three Classes of Psychotropics Can Teach Us About Distinctions Between Gad and MDD” David J. Kupfer Ellen Frank 105

5 Psychometric Aspects of Anxiety and Depression David Goldberg 109

Commentary On “Psychometric Aspects of Anxiety and Depression” Patrick E. Shrout 125

6 The Boundary Between Generalized Anxiety Disorder and the Unipolar Mood Disorders: Diagnostic and Psychometric Findings in Clinical Samples Timothy A. Brown 131

7 Major Depression and Generalized Anxiety Disorder in the National Comorbidity Survey Follow-Up Survey Ronald C. Kessler Michael Gruber John M. Hettema Irving Hwang Nancy Sampson Kimberly A. Yonkers 139

8 The Relationship of Generalized Anxiety Disorder and Major Depression Over Time Valery N. Krasnov 171

9 Generalized Anxiety Disorder and Major Depression: Common and Reciprocal Causes D.M. Fergusson L. J. Horwood 179

10 Confirmatory Factor Analysis of Common Mental Disorders Across Cultures K.S. Jacob Martin Prince David Goldberg 191

Commentary On “Confirmatory Factor Analysis of Common Mental Disorders Across Cultures” Dan J. Stein Vikram Patel Gerhard Heinze 211

11 Generalized Anxiety Disorder and Depression: Childhood Risk Factors in a Birth Cohort Followed to Age 32 Years Terrie E. Moffitt Avshalom Caspi HonaLee Harrington Barry Milne Maria Melchior David Goldberg Richie Poulton 217

12 Are There Early Adverse Exposures that Differentiate Depression and Anxiety Risk? Marcus Richards David Goldberg 241

13 Episodes and Disorders of General Anxiety and Depression Ian M. Goodyer 257

14 Are Major Depression and Generalized Anxiety Disorder the Same or Different Disorders? Discussion of the Dunedin and Medical Research Council Birth Cohort Studies and the Three-Generation High Risk Study Myrna M. Weissman Virginia Warner Priya Wickramaratne 271

15 Toward a Primary-Care Friendly DSM-V Classification of Emotional Disorders: An Integrative Approach J. Ormel M. J. Manley 285

16 Psychosocial Origins of Depressive and Anxiety Disorders George W. Brown 303

Commentary On “Psychosocial Origins of Depressive and Anxiety Disorders,” Part 1 Sidney Zisook 333

Commentary On “Psychosocial Origins of Depressive and Anxiety Disorders,” Part 2 Donna E. Stewart 347

17 The Relationship between Generalized Anxiety Disorder and Major Depressive Episode David Goldberg 355

Index 363

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