Chimpanzees in Biomedical and Behavioral Research:: Assessing the Necessity

Chimpanzees in Biomedical and Behavioral Research:: Assessing the Necessity

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Overview

For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Product Details

ISBN-13: 9780309220392
Publisher: National Academies Press
Publication date: 12/05/2011
Pages: 200
Product dimensions: 6.00(w) x 9.00(h) x 0.60(d)

Table of Contents

Summary 1

Study Background and Context 9

Origin of Study and Committee Statement of Task 12

Ethical Considerations 14

Methods and Organization of the Report 15

International Policies Guiding Chimpanzee Use 16

Summary of Chimpanzee Research 20

Analysis of Federally Supported Research 20

Analysis of Private-Sector Supported Research 23

Criteria That Guide the Current Use of Chimpanzees 25

Principles Guiding the Use of Chimpanzees in Research 26

Ethologically Appropriate Physical and Social Environments 27

Criteria to Assess the Necessity of the Chimpanzee for Biomedical Research 28

Criteria for Use of the Chimpanzee in Comparative Genomics and Behavioral Research 33

Reviewing the Necessity of Current Chimpanzee Research 35

Monoclonal Antibodies 36

Development of Chimpanzee Monoclonal Antibodies 37

Safety Testing of Monoclonal Antibody Therapies 38

Respiratory Syncytial Virus 42

HCV Antiviral Drugs 47

Therapeutic HCV Vaccine 50

Prophylactic HCV Vaccine 52

Comparative Genomics 55

Altruism 59

Cognition 62

Future Use of Chimpanzees in Biomedical and Behavioral Research 64

Conclusions and Recommendations 66

Appendixes

A References 71

B Commissioned Paper: Comparison of Immunity to Pathogens in Humans, Chimpanzees, and Macaques 91

C Information-Gathering Agendas 167

D Committee Biographies 181

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