Arteriovenous and Cavernous Malformations, Volume 143, is the latest addition in the ongoing HCN series, an evidence-based compendium which addresses both the scientific and clinical aspects of this unique disease process. The volume covers didactic aspects, such as the epidemiology, etiology, and diagnosis of AVMs, while also providing expert clinical information on the management and treatment of these lesions.
In addition, it provides coverage of modern-day advances in the genetics of cavernous malformations, as well as discussion regarding future open research questions. Readers from the laboratory bench to the bedside can expect a broad, yet objective, review of this pathology, with updates from the latest scientific literature and data supporting current practices.
- Offers an evidence-based focus with coverage of both the scientific and clinical aspects of cavernous malformations
- Addresses epidemiology, etiology, diagnosis, and genetics
- Contains clinical insights regarding indications for surgery, surgical techniques, outcomes, and prognostic factors drawn from the authors' extensive experiences
- Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available
About the Author
Dr. Spetzler is President and Chief Executive Officer of Barrow Neurological Institute in Phoenix, Arizona, where he has been Director since 1986 and has held the J. N. Harber Chair of Neurological Surgery since first joining the staff in 1983. Under his guidance and focus on education, research, and patient care, Barrow Neurological Institute has become one of the top neuroscience centers and the largest neurosurgical center in the United States, with the largest neurosurgical residency training program in the country.
His neurosurgical work focuses on vascular neurosurgery and skull base surgery to treat aneurysms, arteriovenous malformations (AVMs), and cavernous malformations. He has developed more effective and safer neurosurgical approaches to deep areas of the brain. During his extensive surgical practice, he has clipped more than 6,400 aneurysms, and he has developed theories on normal perfusion pressure breakthrough and how AVM size reveals the potential for rupture. He codeveloped a heuristic grading system (the Spetzler-Martin grading scale) for estimating the risk of open neurosurgery for AVMs.
Dr. Spetzler is a sought-after presenter at national and international neurosurgical conferences. He has edited or coedited more than 20 books and neurosurgical atlases, has published more than 700 articles in peer-reviewed academic medical journals, and has coauthored more than 270 book chapters. He frequently serves as a peer reviewer of scholarly manuscripts on vascular topics. He has been editor-in-chief of the journals Operative Techniques in Neurosurgery and Skull Base: An Interdisciplinary Approach, and he has been an editorial board member, a section editor, and an advisory board member for numerous journals.
He holds chairs in Neurosurgical Education and in Neurosurgical Research at Barrow Neurological Institute, and serves as a professor and executive chair of the Department of Neurosurgery at the University of Arizona College of Medicine, Phoenix. He also is a past president of the American Academy of Neurological Surgery and the North American Skull Base Society, and a past honorary president of the World Federation of Neurosurgical Societies Foundation.
Dr. Karam Moon is a fellowship-trained cerebrovascular neurosurgeon in Phoenix, Arizona. He received his Bachelor of Science from the University of Washington in Seattle, Washington and attended medical school at Case Western Reserve University in Cleveland, Ohio. He completed his neurosurgical residency training under Dr. Robert Spetzler at the venerable Barrow Neurological Institute in Phoenix, Arizona, where he also completed his fellowship training in endovascular neurosurgery under Drs. Cameron G. McDougall and Felipe C. Albuquerque. He is a prolific academic neurosurgeon, regularly publishing clinical outcomes studies in leading neurosurgery journals and speaking at national conferences throughout the year. He was also the recipient of two consecutive Synthes Cerebrovascular Awards in the 2014-2015 academic year. He also served as a sideline concussion consultant for Arizona State University Football during the 2014 season. In his spare time, he enjoys a variety of sports, mountain biking, and traveling.
Rami Almefty is a chief resident in neurological surgery at Barlow Neurological Institute. He received his medical degree from the University of Arkansas, and he completed a skull base fellowship at Harvard Medical School. His neurosurgical interests are skull base and cerebrovascular surgery.
Table of Contents
PART I. ARTERIOVENOUS MALFORMATIONS Section 1. Cerebral Arteriovenous Malformations 1. Epidemiology, genetics, pathophysiology and prognostic classifications of cerebral arteriovenous malformations 2. The natural history of cerebral arteriovenous malformations 3. Arteriovenous malformations: epidemiology, clinical presentation and diagnostic evaluation 4. Seizures Associated with Cerebral Arteriovenous Malformations 5. Surgical Management 6. Endovascular management of arteriovenous malformations 7. Radiosurgery for the management of cerebral arteriovenous malformations 8. Multimodality Management Section 2. Cerebral Dural Arteriovenous Fistulas 9. Epidemiology, clinical presentation, diagnostic evaluation, and prognosis of cerebral dural arteriovenous fistulas 10. Surgical management of cerebral dural arteriovenous fistulae 11. Endovascular Management 12. Radiation Management Section 3. Spinal Vascular Malformations 13. Classification and pathophysiology of spinal vascular malformations 14. Epidemiology, Clinical Presentation, Diagnostic Evaluation and Prognosis 15. Spinal Arteriovenous Malformations: surgical management 16. Endovascular treatment of spinal arteriovenous malformations 17. Spinal Arteriovenous Malformations: radiation management 18. Spinal Arteriovenous Fistulas: surgical management 19. Spinal Arteriovenous Fistulas: endovascular management 20. Spinal subarachnoid hemorrhage and aneurysms Section 4. Animal models 21. Animal models of arteriovenous malformation PART II. CAVERNOUS MALFORMATIONS 22 Natural History of Cerebral Cavernous Malformations 23 Natural History of Spinal Cavernous Malformations 24 Genetics of Cavernous Malformations 25 Epidemiology of Cavernous Malformations 26 Radiology and Imaging for Cavernous Malformations 27 Pathology of Cavernous Malformations 28 Developmental Venous Anomalies 29 Supratentorial Cavernous Malformations 30 Brainstem and Cerebellar Cavernous Malformations 31 Thalamic Cavernous Malformations 32 Spinal Cavernous Malformations 34 Pharmacotherapy for Cavernous Malformations