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A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution

A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution

by Jennifer A. Doudna, Samuel H. Sternberg

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Overview

BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY  |  Finalist for the Los Angeles Times Book Prize
  
“A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books 
 
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life.

“The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas

“An invaluable account . . . We owe Doudna several times over.” — Guardian


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Product Details

ISBN-13: 9781328915368
Publisher: HarperCollins Publishers
Publication date: 08/21/2018
Edition description: Reprint
Pages: 304
Sales rank: 107,623
Product dimensions: 5.20(w) x 7.90(h) x 1.00(d)

About the Author

JENNIFER A. DOUDNA, Ph.D. is a professor in the Chemistry and the Molecular and Cell Biology Departments at the University of California, Berkeley, investigator with the Howard Hughes Medical Institute, and researcher in the Molecular Biophysics and Integrated Bioimaging Division at the Lawrence Berkeley National Laboratory. She is internationally recognized as a leading expert on RNA-protein biochemistry, CRISPR biology, and genome engineering. Along with Emmanuelle Charpentier, she was awarded the 2020 Nobel Prize in Chemistry for their research on CRISPR-Cas9. She lives in the Bay Area.



DR. SAMUEL H. STERNBERG is a protein-RNA biochemist and author of numerous high-profile scientific publications on CRISPR technology. He runs a research laboratory at Columbia University, where he is assistant professor in the Department of Biochemistry and Molecular Biophysics. He lives in New York City.
 

Table of Contents

Prologue: The Wave xi

Part I The Tool

1 The Quest for a Cure 3

2 A New Defense 35

3 Cracking the Code 60

4 Command and Control 86

Part II The Task

5 The CRISPR Menagerie 117

6 To Heal the Sick 154

7 The Reckoning 184

8 What Lies Ahead 213

Epilogue: The Beginning 241

Acknowledgments 247

Notes 250

Index 270

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